You can use the Cells or Range property to refer to a single cell by using row and column index numbers.
In the following example, Cells[5,2] returns cell B5 on Sheet1. The Value property is then set to 10.
[C#]
//variant 1
book.Worksheets[1].Cells[5,2].Value = 10;
//variant 2
book.Worksheets[1].Range[5,2].Value = 10;
[Visual Basic]
'variant 1
book.Worksheets(1).Cells(5,2).Value = 10
'variant 2
book.Worksheets(1).Range(5,2).Value = 10
[C++]
//variant 1
book->Worksheets->Item[1]->Cells->Item[5,2]->Value = 10;
//variant 2
book->Worksheets->Item[1]->Range->Item[5,2]->Value = 10;
IRange.Item[int, int] Property